PaintScape System and CosMx WTX enables in situ direct visualization of 3D genome changes and spatial gene expression in single breast cancer cells
PaintScape™ in situ, single-cell direct visualization of 3D genome organization in ER+ and HER2+ breast cancer cell lines
PaintScape integrated 3D genome, transcriptome, and proteomic assays simultaneously observed genome architecture and transcriptional activity at single-cell resolution
A combined approach using PaintScape and CosMx revealed how disruptions in genome organization drive disease mechanisms in ER⁺ breast cancer by linking altered chromatin topology to dysregulated expression of key oncogenic pathway genes
Using PaintScape™ to directly visualize and map single cell spatial 3D genome landscapes of localized and metastatic breast cancer sub-types
PaintScape™ directly visualized and characterized in situ structural and conformational changes of oncogenic pathway genes in cell lines from different stages of breast cancer (BC) progression
