Congratulations to Dr. Frank Mason — winner of the PaintScape TAP Grant!
PaintScape | overview | Bruker Spatial Genomics, Inc.

Platform overview

PaintScape™ System

For high-plex, direct visualization of the genome in situ in single cells with jebFISH™ Technology

The PaintScape™ System

A revolutionary spatial biology platform for visualizing the 3D genome directly in situ

The PaintScape™ System is a high-resolution, highly multiplexed spatial biology genome analysis platform for direct visualization of the 3D genome in situ in single cells and combines state-of-the-art optics, sophisticated bioinformatics, and a reagent system based on powerful jebFISH chemistry.

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The PaintScape platform includes:

High-performance, robust instrumentation
Genome analysis assay kits
Sample carrier slides
Image and data analysis software tools

PaintScape Genome Painting Provides IN SItu INsights

overview of jebFISH on the PaintScape™ platform

Examples of PaintScape IN Situ Chromosome Traces in different cell types

MCF-7 cell

PaintScape-data-chromotrace-MCF7-OncoPaint-1000+

Human CRC Tissue

PaintScape in situ chromosome traces in single cells of fresh frozen colorectal carcinoma tissue

HER2+ breast cancer cells

all chromosome view of PaintScape chromosome traces of HCC 1954
The PaintScape™ platform enables you to directly visualize multi-loci interactions in healthy vs diseased cells

PaintScape direct visualization of the 3D genome elucidates mechanisms of dysregulation that correlate to disease

Visualize and compare differences in ploidy, chromosome openness, or the proximity of multiple genomic regions of interest

Proximities of multi-loci interactions of genomic regions
Focal amplifications, segmented copy number variation
Ploidy aberrations, p-arm/q-arm variations
Translocations and ecDNA formation
Genomic structural boundary aberrations, TAD-level information
Degree of genomic region accessibility and openness
and more…

Perform unprecedented multiplexed visualization of genome architecture and chromosomal structure directly in situ in single cells with the jebFISH-technology-powered PaintScape™ platform for direct genome visualization. PaintScape traces chromosomes directly in situ and reveals genome organization structure at different levels of scale—from ploidy and chromosomal aberrations and focal amplifications to A/B compartment analysis to structural boundary disruptions and TAD-level information. (see scientific posters and featured PaintScape data for examples)

Examples of In Situ Genome Insights Revealed by PaintScape

Chromosome Ploidy and
Multi-loci Proximities in situ

PaintScape image of IMR90 cell painted with a 1000+ plex OncoPaint panel
PaintScape chromosome traces of IMR90 cells with a 1000+ plex OncoPaint HuCL Cancer Pathways Panel visualized the locations and shapes of chromosome territories (all chromosome view)

Translocations
and Aneuploidy

PaintScape data image from jebFISH on MCF7
PaintScape high-plex genome imaging of MCF-7 with the ChromoPaint PanChromo MPX kit visualized a translocation from Chr 6 to 3 as well as aneuploidy of Chr 3.
(only Chr 3 and 6 displayed for clarity)

Focal Amplifications
and ecDNA

focal amplifications visualized with jebFISH on PaintScape
PaintScape direct genome visualization with the 400+ plex ChromoPaint kit revealed focal amplifications of segments of Chr 20 in MCF-7 cells and visualization of ecDNA indication (circled in blue)
See more PaintScape data

See genome architecture directly in situ in single cells with PaintScape

and elucidate structural genome mechanisms of cell programming or dysregulation

Highly multiplexed, genome-wide characterization of genome organization directly in situ in cells or FF tissue
Unprecedented ability to trace chromosomes and even individual homologs directly in situ in single cells
Groundbreaking ability to directly see genome structural changes in situ in your sample
Reveal novel structural genome mechanisms of cell dysregulation
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Simultaneous chromosome traces from a 1000+ plex PaintScape genome painting of MCF10a with the OncoPaint Cancer Pathways Kit 1
All-chromosome view of chromosome traces directly visualized in situ in an MCF10a cell using the groundbreaking PaintScape platform. An 1000+ plex OncoPaint Cancer Pathways panel was used to paint genome-wide architecture as well as select cancer pathway gene regions with finer detail (often with TAD-level detail).

Adding the Genome to your Spatial Omics

Instruments

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assays

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accessories

PaintScape cell sample chips icon
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Data ANALYSIS

PaintScape™ data analysis
Data example

PaintScape — a revolutionary way to study genome architecture genome-wide directly in situ in single cells

The PaintScape™ System
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PaintScape Inquiry

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Request a meeting to learn how PaintScape can help you discover novel genome insights.

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