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Visualize the 3D genome

A new frontier in genome analysis

in situ spatial analysis of genome organization
with jebFISH™ technology from Bruker

Directly visualize the 3D genome in single cells with jebFISH multiplexed genome imaging on PaintScape

Perform unprecedented multiplexed visualization of genome architecture and chromosomal structure in single cells with jebFISH technology on the groundbreaking PaintScape™ platform.

Accelerate your research with jebFISH direct genome imaging
Unique ability to see genome organization or disruption in single cells and with single chromosome detail
The power of jebFISH technology makes it practical and accessible
jebFISH highly multiplexed 3D genome imaging

Trace individual chromosome homologs

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jebFISH chromatin traces imaged on the PaintScape Imaging instrument
See individual chromosome homologs traced in situ in single-cell nuclei

in situ Single-nuclei Images

View chromosome-specific PaintScape image overlays

PaintScape images from a high-plex, genome-wide jebFISH powered study of chromosome architecture in a human cell line. Chromosome-specific traces can be viewed in single image overlays or together in different combinations.

Click on text in tabs below to view chromosome-specific overlay images. Or view ALL chromosomes.

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PaintScape chromosome trace image from a 578-plex jebFISH analysis of a human cell line.

use jebFISH to visualize multi-loci interactions in healthy vs diseased cells

Explore genome organization linkages to cell programming and dysregulation in different cell types

Visualize and compare differences in chromatin openness or the proximity of multiple genomic regions of interest such as:

Non-coding and coding regions of interest
Cancer driver genes and their regulatory regions
Known chromosome breakpoints or regions of aberrant ploidy or structure

3D GENOME INSIGHTS

Gain new insights into mechanisms of disease with jebFISH direct genome imaging

Deeper understanding of genome organization elucidates keys to mechanisms of disease and its progression.

disruptions of 3D genome can drive disease

Until now, studying the 3D genome has been limited and could not easily provide information at single cell resolution or at the level of individual chromosome homologs.

jebFISH analysis on the PaintScape platform breaks through those challenges and delivers transformative new insights.

jebFISH genome painting on the PaintScape System enables transformative new study of genome organization through high performance, high resolution genome imaging.

Biological Insights

Directly see changes or disruptions in genome organization that impact cell state and cell programming.

Biological insights from jebFISH on the PaintScape System

Check back soon!

Exciting details, product information, and application examples coming soon!

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