POSTERS
AACR 2026 | poster #789
PaintScape enables in situ, single cell spatial multiomic visualization of 3D genome organization in fresh frozen colorectal carcinoma tissue in spatially resolved tissue microenvironments
highlights
PaintScape™ enabled identification, characterization, and direct in situ visualization of single cell 3D genome features of different cell types in FF colorectal cancer tissue across different patients.
PaintScape™ revealed distinct structural genotypes between individual single cells from different cell sub-popluations (e.g., cancer vs normal cells).
PaintScape revealed ecDNA copy number, nuclear locations, and in situ interactions in single cells of FF colon cancer tissue
PaintScape unveiled differences in inter-chromosomal interactions, potential translocations, and simultaneous proximities of multi-loci interactions in situ in single cells from different patients
PaintScape revealed cell-type-specific differences in 3D genome structure in situ in single cells in the tissue immune microenvironment
PaintScape revealed multiomic correlations of cancer cell states between patients