Platform overview

PaintScape™ System

For high-plex, direct visualization of the genome in situ in single cells with jebFISH™ Technology

The PaintScape™ System

A revolutionary spatial biology platform for visualizing the 3D genome

The PaintScape™ System is a high-resolution, highly multiplexed spatial biology genome analysis platform for direct visualization of the 3D genome in situ in single cells and combines state-of-the-art optics, sophisticated bioinformatics, and a reagent system based on powerful jebFISH™ chemistry.

The PaintScape platform comprises:

High-performance, robust instrumentation

Genome analysis assay kits

Sample carrier slides

Image and data analysis software tools

jebFISH Genome Painting on the PaintScapE System

overview of jebFISH on the PaintScape™ platform

Instruments

assays

accessories

Data ANALYSIS

Adding the Genome to your Spatial Omics

use jebFISH to visualize multi-loci interactions in healthy vs diseased cells

PaintScape direct visualization of the 3D genome elucidates mechanisms of dysregulation that correlate to disease

Visualize and compare differences in ploidy, chromosome openness, or the proximity of multiple genomic regions of interest

Proximities of multi-loci interactions of genomic regions

Focal amplifications, segmented copy number variation, and other ploidy aberrations

Translocations and ecDNA formation

Genomic structural boundary aberrations

Degree of genomic region accessibility and openness

and more…

Learn about jebFISH genome painting

See featured PaintScape data

Why the 3D genome

EXAMPLES of PaintScape 3D Genome Insights

focal amplifications visualized with jebFISH on PaintScape — Focal amplifications of Chr 20
in MCF-7 cells

translocations on MCF7 visualized with jebFISH on PaintScape — Translocations from Chr 6 to Chr 3 in MCF-7 cells

ploidy variation in a glioblastoma cell line visualized with jebFISH on PaintScape — Extra copies of Chr 7 in a glioblastoma cell line (GSC17)

Talk to our expert team

Request a meeting to learn how PaintScape can help you discover novel genome insights.