The 3D genome plays an important role in cell programming but has been less studied
While the human genome has been fully sequenced, the organization of the genome remains less studied and yet plays a key role in cellular programming and function. Thus, although all cells theoretically have a full set of “genomic blueprints” (a full genome) to carry out cellular functions, the organization and structure of the genome (not just its linear sequence) within each cell has impact on the regulation of those cellular programs and their dysfunction when things go awry.
Chromatin folding patterns can reveal key insights
In fact, only 2% of the genome carries protein-coding DNA; the other 98% includes critical regulatory regions such as enhancers and promoters. Thus, the dynamic folding and unfolding of sections of chromatin (especially those containing regulatory elements) within each cell is critical to its ability to regulate cell division, gene expression, and regulatory pathways.
Genome Composition
The breakthrough ability to investigate genome organization with the jebFISH-powered PaintScape spatial 3D genome analysis platform opens up a new scientific frontier and will reveal novel insights and discovery in genome biology for health and disease.
